Jose Tapia-Ramirez*, Rocio Villalobos Manzo, Emmanuel Rios Castro, Goldie Oza and Manuel Hernandez-Hernandez
The Small Cell Lung Cancer (SCLC) is a lethal malignancy associated with a poor prognosis worldwide. SCLC accounts for 15%-20% of diagnosed lung cancers. It is different (pathological, molecular, biological, and clinical) from other lung cancers, provoking a low quality of life in patients. To this end, alternative diagnosis and treatment methods are nowadays mandatory. This work contributes to those studies based on nanomedicine for diagnosis and treatment of SCLC by using core-shell magnetic nanoparticles functionalized with a linker and drugs. In particular, this contribution aims, on the one hand, at identifying the overexpressed receptor in tumorous cells to select the best target for the functionalization of Core-Shell Nanoparticles (CSNPs) and, on the other hand, at evaluating the residence time distribution of non-functionalized core-shell magnetic nanoparticles, in vivo. The latter focuses on assessing the performance of nanoparticles as a contrast-based diagnostic method during the Enhanced Permeation and Retention (EPR) effect; Magnetic Resonance Images (MRI) are used to characterize the residence distribution time of the nanoparticles in vivo.
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