薬理学と毒性学

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The Art and Science of Drug Design: Pioneering Breakthroughs in Medicine

Elisa Nunna

Drug design plays a pivotal role in the development of new therapeutic interventions to combat a wide range of diseases. It involves a multidisciplinary approach that combines elements of chemistry, biology, computational modeling, and pharmacology to create effective and safe medications. This abstract provides an overview of the principles and methodologies involved in modern drug design, highlighting the innovations and challenges in this dynamic field. The process of drug design begins with the identification of a specific disease target, such as a protein or enzyme involved in the disease pathway. Researchers employ various techniques, including high-throughput screening, virtual screening, and structure-based design, to identify and optimize potential drug candidates. Advances in computational modeling and simulation have revolutionized drug discovery, enabling the prediction of molecular interactions and properties to guide the design process. The complex nature of diseases, with their intricate molecular pathways and genetic variability, poses significant hurdles in identifying suitable targets and designing effective drugs. Moreover, issues such as drug resistance, toxicity, and the high attrition rate in clinical trials add to the challenges faced by researchers. drug design is a dynamic and evolving field that continues to drive advancements in modern therapeutics. Through the integration of diverse disciplines and innovative approaches, researchers strive to develop safe and effective drugs to address unmet medical needs. Overcoming the challenges associated with drug design requires ongoing collaboration, technological advancements, and a deep understanding of disease biology, paving the way for improved treatment options and better patient outcomes [1, 2]. Drug design is a dynamic and evolving field that continues to drive advancements in modern therapeutics. Through the integration of diverse disciplines and innovative approaches, researchers strive to develop safe and effective drugs to address unmet medical needs. Overcoming the challenges associated with drug design requires ongoing collaboration, technological advancements, and a deep understanding of disease biology, paving the way for improved treatment options and better patient outcomes [3].

Drug design; Drug discovery; Medicinal chemistry; Molecular modelling