Henry Bassemer*, Robert Hookre
Mitochondria, the powerhouses of the cell, play a critical role in maintaining immune cell health and promoting optimal immune responses. Beyond their primary function of energy production, mitochondria contribute to a range of vital cellular processes in immune cells, including calcium signaling, reactive oxygen species (ROS) generation, metabolic reprogramming, and cell fate decisions. Proper mitochondrial function is essential for immune cell activation, differentiation, proliferation, and effector functions. Dysregulation or impairment of mitochondrial function in immune cells has been associated with immune-related disorders such as autoimmune diseases, chronic inflammation, and immunodeficiency syndromes. This article provides an overview of the multifaceted roles of mitochondria in immune cells and emphasizes their significance in preserving immune health. Understanding the interplay between mitochondria and immune cells holds promise for developing novel therapeutic strategies to modulate immune responses and combat immune-mediated diseases.
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