トランスレーショナル生物医学

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In vitro antiviral activity of honey against varicella zoster virus (VZV): A translational medicine study for potential remedy for shingles

Aamir Shahzad , Randall J Cohrs

Objectives: The aim of this study was to determine the in vitro anti-viral effectof honey on varicella zoster virus.

Methods: Manuka and clover honeys were used at concentrations ranging from0-6% wt/vol. A clinical VZV isolate was obtained from a zoster vesicle and used atlow passage. Various concentrations of manuka and clover honey were added to thetissue culture medium of VZV-infected human malignant melanoma (MeWo) cells.

Results: Both types of honey showed antiviral activity against varicella zoster viruswith an approximate EC50 = 4.5 % (wt/vol).

Conclusions: Our results showed that honey has significant in vitro anti-VZVactivity. As, honey is convenient for skin application, is readily available and inexpensive,honey may be an excellent remedy to treat zoster rash in developingcountries where antiviral drugs are expensive or not easily available.