Atul Bagdane1*,Nilima Thombre1
The objective to develop the formulation & evaluate medicated chewing gum as specialised drug delivery system.improved bioavaibility & patient compliance. Methods & Materials Medicated chewing gum were prepared by Direct compression method using Health in Gum grade -01(HiG-01) as a directly compressible gum base developed by Cafosa (S.A.U.),spain.The effect of concentration of (Base) Gum Base ,( released modifier) Aerosil, and ( antiaderant) talc was studied with the study of potential factors affecting drug release by 32 full factorial experimental design.
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