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Formulation and Evaluation of Herbal Oral Gel Containing Extracts of Powdered Psidium guajava Linn Leaves with Curcuma longa Linn Rhizomes toTreat Mouth Ulcer

Richa Sing*, Sagar Bansal and Manoj Kumar Mishra

The objective of this study was to formulate and evaluate the herbal oral gel containing extracts of powdered Psidium guajava Linn leaves and Curcuma longa Linn rhizomes to treat mouth ulcer. The traditional medical study is an integral part of the culture and the interpretation of health by indigenous populations in almost world. Guava leaves have been usually used to govern several diseases such as rheumatism, diarrhea, diabetes mellitus, wound sore throat, cough and it also gives good antimicrobial, antifungal, anticancer activity. Guava comprises some essential phytoconstituents such as tannins, triterpenes, flavonoid: quercetin, pentacyclic triterpenoid: guajanoic acid, saponins, carotenoids, lectins, leucocyanidin, ellagic acid, amritoside, betasitosterol, uvaol, oleanolic acid and ursolic acid while turmeric has anti-inflammatory, antibacterial activity, virucidal, antimutagenic, antioxidant properties. Turmeric contains a large variety of phytochemicals such as curcumin, demethoxycurcumin, eugenol, tannins, alkaloids, saponins, terpenoids and curcumol. The herbal oral gel formulation was prepared by using guava leaf extract, turmeric rhizome extract, carbopol 934, propylene glycol, methyl paraben, propyl paraben, triethnolamine and required amount of distilled water. The triethanolamine was added drop wise to maintain the pH (6.7-7.2) of oral mucosa. The physicochemical parameters of formulations such as pH, spreadability, viscosity, extrudability, gelling strength and antifungal activity were determined. The results showed that the optimized herbal oral formulation containing guava leaf extract and turmeric rhizomes extract shows that all physicochemical parameters were found to be compatible with the normal range. Anti-fungal study of formulation revealed excellent efficacy against Candida albicans. Developed herbal oral formulation was stable, safe and effective for the treatment of mouth ulcer.