Ning Xiao1,2,3,4*, Qi Tang2,3, JianFeng2 and HuaSheng Zhao2,3*
Lower Urinary Tract Infections (LUTIs) are regarded as the most frequent form of bacterial infections and bladder Detrusor Overactivity (DO) are considered to contribute to (OAB), including urinary urgency, urinary frequency, with or without Urgency Incontinence (UI), which is common disorder and influences patient's health and quality of life. Since 1960s, studies had focused on whether DO is the etiological factors of recurrent LUTIs or the inverse. Although the definite correlation between DO and LUTIs have not been proved, urinary microbiota may play a role in genesis of DO that was found by mounting evidences using enhanced urine culture technique and pathophysiological variations of bladder detrusor facilitates bacterial colonization in bladder urothelium. In the future, clarification of correlation between DO and LUTIs needs more scheduled studies and more researches that link the urinary microbiota with Central Nervous System (CNS) function to provide accurately information to help us manage the patients more appropriately.
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