Jyotsna Sethi 1*, Chandrajeet Kumar 2 , Arun Kumar2
In the recent times, the lung cancer disease burden in the population has increased manyfolds globally. Among those carcinogen- Benzo[A]pyrene is one of the known which is directly responsible for the cause. Benzo(a)pyrene has been shown to inflict damage on the lungs as well as liver. Thus, the present study has been aimed to study the anticancer activity of Aegle marmelos fruit pulp extract on Benzo [A] pyrene induced lung cancer in rats. Thirty male Charles Foster rats, 6 weeks old weighing around (150-180 g) were used for the study and were induced Benzo[A] pyrene (25 mg/Kg dissolved in Olive oil) orally in two intervals (1st day and 14th day) and were left for 3 months. After 3 months, there was development of lung tumours, which were confirmed histopathologically. Thereafter, Aegle marmelos fruit pulp extract at the dose of 250mg/Kg body weight was administered to the rats for 5 weeks. After the treatment there was significant reduction in the lung tumour size was observed in the studied rats. All the parameters were studied and their data were analysed. The haematological parameters, the biochemical parameters and the histopathological parameters were also correlated for the efficacy of the drug.
Through the entire study, it can be concluded that, fruit pulp extract of Aegle marmelos possesses anticancerous effect against Benzo [A]pyrene induced lung cancer. This drug after various trials can be recommended as therapeutic drug for lung cancer disease in the future.
KeywordsBenzo[A]pyrene induced lung model; Tumour volume; Biochemical parameters study; Histopathological study; Fruit pulp extract of Aegle marmelos; Novel drug discovery
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