Bolodeoku J*, Bains S, Pinkney S, Coker O, Kim TK and Anyaeche C
The objective of this study was to evaluate the precision and accuracy of the Boditech i-CHROMA™ TSH method. In this study, the inter and intra assay precision was < 10% and there was very good correlation (r2>0.97) between the Boditech i-CHROMA™ TSH method and the following methods: Abbott Architect, BioMerieux Vidas TSH, BioMerieux Vidas TSH3 Ultrasensitive, Roche COBAS® 6000/8000, Siemens Centaur XP/XPT/Classic, Siemens Centaur XP/XPT/Classic 3rd generation, Siemens Centaur XP/XPT/Classic TSH3 Ultra, Siemens Dimension, Siemens Immulite, Siemens Immulite 1000, Beckman DXI 600/800 Fast TSH, Beckman DXI 600/800 Hyper TSH, Roche Elecsys, DiaSorin Liaison, Monobind Inc ELISA/CLIA, Roche COBAS® 4000/e411, Roche Modular E-170, Beckman Access/ LXi725 hyper TSH 3rd generation, Tosoh, Ortho Vitros 3600/5600/ECi. The Boditech i-CHROMA™ TSH method was negatively biased compared to the other methods, with a range between -0.6 uIU/mL and -3.25 uIU/mL with an average of -1.93 uIU/mL. In addition, the Boditech i- CHROMA™ method identified 18/18 (100%) all the samples grouped as TSH <0.4 uIU/mL and 0.4 – 4.0 uIU/mL. However, the Boditech i-CHROMA™ method was only able to identify 15/18 (83%) of the samples with >4 uIU/mL. In conclusion, the Boditech i-CHROMA™ TSH method which is a quantitative method showed very good precision and reasonable accuracy with the other laboratory methods and therefore useful for the diagnosis and management of primary hypothyroidism.
English 
Spanish 
Chinese 
Russian 
German 
French 
Portuguese 
Hindi