Imam Razi*, Mishra Amul
The present work is aimed to develop a stable formulation of preferred combination of two Antibiotics Amoxycillin and Potassium Clavulanate by using various disintegrants.They are Prepared by direct compression method using different disintegrant i.e croscarmellose Sodium, cross povidone, Maize Starch and sodium starch Glycolate. Aspartame as sweetener and strawberry flavours were used to increase palability. The powder blends were subject to various characterstics test such as bulk density, tapped Density, Haushners ratio and combressibility index. These tablets were evaluated for hardness, friability, disintegration time and wetting time and in vitro drug release. Amoxycillin and Potassium clavulanate dispersible tablets were found to be of good quality fulfilling all the requirements for dispersible tablets.The result indicated that concentration of cross povidone, cross carmellose sodium, sodium starch glycolate and maize starch significantly affected the release property of the drug. Cross carmellose sodium showed high disintegration time as compared to batches prepared from maize starch, sodium starch glycolate and cross povidone. The optimized batch tablets were packed in Alu Alu pack and performed stability studies at 40. C/75% RH. There is no change in the physiochemical properties of the tablet during the stability period. Hence the developed dispersible tablet could be found suitable alternate dosage form.
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